青年科学工作者论坛2008年第5期

赵长峰  王惠敏¹  张俊黎²  冯丽³  刘言训  邹凌燕  胡琴静

山东大学公共卫生学院，济南  250012

摘要：目的  了解糖尿病患者与正常人群血清微量元素含量的差异，并探讨微量元素与糖尿病患者血糖、人体成分测量指标之间的关系。方法  随机选取糖尿病患者72名作为病例组，64名健康体检者作为对照组。分别测量病例组和对照组的血清锌、硒、锰、镉、铁、铅、铜、镍、钴、锂、铬含量，铜锌比值，比较两组间差异，并与血糖及蛋白质含量、矿物质含量、脂肪含量、瘦体重、腰围、臀围等人体成分指标进行相关性分析。结果  2型糖尿病患者血清锌、硒、铬含量显著低于对照组(P<0.05)，血清铜含量则显著高于对照组(P<0.05)，其他元素差异没有显著性。血清锌与血糖呈微弱负相关，铜与血糖呈正相关(P<0.01)。铜与腰围呈微弱正相关(P<0.01)，锰与蛋白质含量、矿物质含量、臀围均呈微弱负相关(P<0.05)。结论  提示纠正2型糖尿病患者体内存在着的微量元素代谢紊乱，对于糖尿病的治疗及预防并发症有重要价值。

关键词：2型糖尿病  微量元素  人体成分  铬  锌  血糖

 

Correlations of serum trace elements, serum glucose and body compositions in type 2 diabetes

ZHAO Changfeng，WANG Huimin，ZHANG Junli，FENG Li, et al.

Department of Nutrition and Food Hygiene, School of Public Health, Shandong University, Jinan 250012, China

Abstract：Objective  To evaluate the difference in trace elements between diabetic and control groups, and to explore the correlations between trace elements and serum glucose, body compositions in patients with type 2 diabetes． Methods  72 diabetics and 64 controls are selected randomly．The level of serum trace elements, the ratio of copper, zinc were measured and compared between the two groups. A correlation was conducted for the serum trace elements, serum glucose and body compositions and 64 controls are selected randomly． Results  There was a very significant difference in some serum trace elements level between diabetic and control groups(P<0.01)．Serum zinc，selenium，chromium were significantly lower in diabetic group compared with the control group(P<0.01)，copper was significantly higher(P<0.01)．Negative correlations were showed between zinc and serum glucose, manganese and the content of protein, the content of trace elements, hip circumference．And positive correlations were showed between copper and serum glucose, copper and waist circumference． Conclusion  It is concluded that there is trace elements metabolism disorder in patients with type 2 diabetic mellitus．The correction for this disorder might have significant value for the treatment of diabetics and prevention of complications．

Key words: type 2 diabetes，trace elements，body composition，chromium，zinc